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Antibiotics canstill kill drug resistant bacteria if they 'push' hard enough into bacterialcells, finds new UCL led research funded by the Engineering and PhysicalSciences Research Council. The study,published in Nature Scientific Reports,opens up a promising new way of overcoming antibiotic resistance and could helpscientists to design even more effective drugs. "Antibioticswork in different ways, but they all need to bind to bacterial cells in orderto kill them," explains lead author Dr Joseph Ndieyira UCL Medicine. "Antibiotics have 'keys' that fit 'locks' on bacterial cell surfaces,allowing them to latch on. When a bacterium becomes resistant to a drug, it effectivelychanges the locks so the key won't fit any more. Incredibly, we found that certainantibiotics can still 'force' the lock, allowing them to bind to and killresistant bacteria because they are able to push hard enough. In fact, some ofthem were so strong they tore the door off its hinges, killing the bacteria instantly!"The researchers usedsensitive equipment to measure the mechanical forces that four differentantibiotics exerted on bacterial cells. They tested bacteria that weresusceptible to antibiotics and those that had developed resistance. Theantibiotics all exerted similar forces on susceptible bacteria, but the forcesthey exerted on resistant bacteria varied significantly. The antibiotics testedincluded vancomycin, a powerful antibiotic used as a last resort treatment forMRSA and other infections, and oritavancin, a modified version of vancomycinused against complex skin infections. "We foundthat oritavancin pressed into resistant bacteria with a force 11,000 timesstronger than vancomycin," says Dr Ndieyira.
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5629683. Both of those things together will increase the frequency with which we see these big rainstorms, and those are likely to increase flooding in the future. Flooding on the Mississippi has become more frequent and more extensive since about 1950, Jefferson said. This years huge flood was created by snowmelt and rain on snow in the upper Mississippi River basin, and very intense rain in its middle regions. Climatically we have a higher frequency of rain on snow events, a real recipe for flooding, she said. Also youre getting more warm, moist air from the Gulf of Mexico farther north up the Mississippi. Its both a warming and, more so, the fact that the weather patterns have changed and are projected to continue to change, so the precipitation patterns are changing. Scientists say these changes are part of the general shift in the worlds climate known as global warming primarily the result of billions of tons of heat trapping gases released into the atmosphere from burning fossil fuels, as well as deforestation. A report by the National Academy of Sciences on managing climate risks put it this way: Climate change is occurring, is very likely caused primarily by the emission of greenhouse gases from human activities, and poses significant risks for a range of human and natural systems. Scientists have observed increases in heavy downpours, rising temperatures, longer growing seasons and earlier snowmelts. They predict that rainfall will become more concentrated in heavy downpours, with longer dry periods in between.
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Repeated cycles of wetting and drying do not faze the lichen, because the fungal partner can re organise its membranes as soon as water appears, allowing photosynthesis to resume. 3 Lichen may be found in frozen tundra and on parched desert rocks. For mushroom lovers, the most intriguing interspecies companionship is that between fungi and plant roots. In mycorrhiza, the threads of the fungal body sheathe or enter the roots of plants. Indian pipes and other plants without chlorophyll are supported entirely from the nutrients they gain from fungi in their roots; many orchids cannot even germinate without fungal assistance. 4 Here plants gain sustenance from fungi; in more cases, however, the fungus obtains sustenance from the plant. But a mycorrhizal fungus is not just selfish in its eating. It brings the plant water and makes minerals from the surrounding soil available for its host. Fungi can even bore into rocks, making their mineral elements available for plant growth. In the long history of the earth, fungi are responsible for enriching soil thus allowing plants to evolve; fungi channel minerals from rocks to plants. 5 Trees are able to grow on poor soils because of the fungi that bring their roots phosphorus, magnesium, calcium, and more.
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, M. Phil. , NET, Ph. D. Error Analysis and Paragraph Writing . Ali Akbar Khansir, Ph. D. Masomeh Ahrami, M. A. ENGLISH AS A SECOND LANGUAGE PROFICIENCY ISSUES OF JAFFNA STUDENTSPrescribed as a Text Book for University Undergraduates . Dr.